Tuesday, January 22, 2008

Drug Safety During Breastfeeding

Whether you're suffering from congestion brought on by allergies or pain associated with a more serious health problem, you're probably ready to head to the medicine cabinet for some relief. Although many medications are safe to use while breastfeeding, almost any drug will get into your milk to some degree and can occasionally affect your milk supply. To be safe, you should always check with your child's doctor before taking any kind of medication, even over-the-counter drugs.

The information in our chart was compiled by Philip Anderson, a pharmacist and the director of the Drug Information Service at the University of California, San Diego Medical Center. If you have more questions about how a drug you're taking might affect your breast milk or your baby, call the UCSD information service at (619) 543-6971, 9 a.m. to 5 p.m. Pacific time, Monday to Friday. Or check the U.S. National Library of Medicine more complete drug database.

Safe to Take in Usual Doses

Name of Drug

Brand Name

Use

Acetaminophen

Tylenol

Used for pain relief

Acyclovir

Zovirax

Antiviral for herpes infections

Antacids

Maalox, Mylanta

Used to treat upset stomachs

Bupivacaine

Marcaine

A local anesthetic

Caffeine

coffee, soft drinks

A stimulant

Cephalosporins

Keflex, Ceclor, Ceftin, Omnicef, Suprax

Antibiotics for lung, ear, skin, urinary tract, throat and bone infections

Clotrimazole

Lotrimin, Mycelex

Used to treat yeast and fungal infections

Contraceptives (Progestin-Only)

Micronor, Norplant, Depo-Provera

Used for birth control

Corticosteroids

Prednisone

Used to treat inflammation of joints and other conditions

Decongestant nasal sprays

Afrin

Used to treat stuffy noses

Digoxin

Lanoxin

Used to treat heart problems

Erythromycin

E-Mycin, Erythrocin

Used for skin and respiratory infections

Fexofenadine

Allegra

Antihistamine for allergies and hay fever

Fluconazole

Diflucan

Used to treat yeast infections

Heparin and LMW Heparins


Keep blood from clotting

Ibuprofen

Motrin, Advil

Used for pain relief

Inhalers, bronchodilators, and corticosteroids

Albuterol, Vanceril

Used for asthma

Insulin


For diabetes; dosage required may drop up to 25 percent during lactation

Labetalol

Normodyne, Trandate

Used for high blood pressure

Laxatives, bulk-forming and stool softening

Metamucil, Colace

Used to treat constipation

Lidocaine

Xylocaine

A local anesthetic

Loratadine

Claritin

Antihistamine for allergies and hay fever

Low molecular weight heparins (enoxaparin, dalteparin, tinzaparin)

Lovenox, Fragmin, Innohep

Anticoagulants

Magnesium sulfate


Used to treat preeclampsia and eclampsia

Methyldopa

Aldomet

Used to treat high blood pressure

Methylergonovine (short courses)

Methergine

Used to prevent or control bleeding after childbirth

Metoprolol

Lopressor

A beta-blocker used to treat high blood pressure

Miconazole

Monistat 3

Used to treat yeast infections

Nifedipine

Adalat, Procardia

Used for high blood pressure and Raynaud's syndrome of the nipple

Penicillins

Amoxicillin, Penicillin VK

Used to treat bacterial infections

Propranolol

Inderal

A beta blocker used to treat heart problems, and high blood pressure

Theophylline

Theo-Dur

Used to treat asthma and bronchitis

Thyroid replacement

Synthroid

Used to treat thyroid problems

Vaccines (except smallpox)



Vancomycin

Vancocin, Vancoled

An antibiotic

Verapamil

Calan, Isoptin, Verelan

Used for high blood pressure

Warfarin

Coumadin

Used to treat or prevent blood clots



Probably Safe in Usual Doses
Little is known about the effects of these drugs on a breastfeeding infant, but if there is an effect, it will probably be mild. In rare cases, a child will have an allergic reaction.

Name of Drug

Brand Name

Use

ACE inhibitors

Enalapril (Vasotec), Benazepril (Lotensin)

Used to treat high blood pressure

Acyclovir and valacyclovir

Zovirax, Valtrex

Antiviral for herpes infections

Anticholinergic agents

Pro-Banthine

Used to treat intestinal and gall bladder spasms; may reduce milk supply

Anticonvulsants

Depakote, Dilantin, Tegretol (avoid ethosuximide, phenobarbital, and primidone)

Used for seizures and mood disorders

Antihistamines

Benadryl, Chlor-Trimeton

May reduce milk supply and cause infant drowsiness or fussiness

Antituberculars

INH

Used to treat tuberculosis

Azathioprine

Imuran

Used to suppress the immune system following organ transplants

Barbiturates (except phenobarbital)

Fiorinal, Fioricet

For sedation and tension headaches

Bupropion

Wellbutrin

For depression

Clindamycin

Cleocin

Used to treat abdominal and vaginal infections

Oral Decongestants

Sudafed, Entex PSE

Used to treat congestion associated with colds or allergies; often reduces milk supply

Ergonovine (short course)


Used to treat uterine bleeding. May reduce milk supply.

Fluconazole

Diflucan

Antifungal

Gadolinium

Magnevist, Omniscan

Contrast agent for MRI studies

Haloperidol

Haldol

Used to treat psychosis

Histamine H2 blockers

Cimetidine (Tagamet), ranitidine (Zantac), nizatadine (Axid), and famotidine (Pepcid — preferred)

Used to treat stomach problems

Hydrochlorothiazide (low doses)

HydroDiuril

Diuretic for high blood pressure

Lorazepam

Ativan

Used to treat anxiety

Methimazole

Tapazole

Used for hyperthyroidism; less than 20 mg/day is probably safe

Metoclopramide

Reglan

Used for gastrointestinal problems and to increase milk supply

Midazolam


Sedative used in anesthesia

Naproxen

Naprosyn, Anaprox, Aleve

Used for pain relief; okay if baby is at least 1 month old

Oxazepam

Serax

Used to treat anxiety

Paroxetine

Paxil

Used to treat depression

Phenothiazines

Compazine (anti-nausea), Stelazine, Thorazine (anti-psychotic)


Propofol

Diprivan

Sedative used in anesthesia

Propylthiouracil (PTU)


Used to treat hyperthyroidism

Quinidine


Used to treat heartbeat irregularities

Quinolone antibacterials

Cipro and Levaquin; Noroxin is preferred

Treatment of urinary tract infections and gonorrhea

Salicylates (occasional use)

Aspirin

Used for pain relief

Sertraline

Zoloft

Used to treat depression

Spironolactone

Aldactone, Aldactazide

Used to treat high blood pressure

Sulfisoxazole

Gantrisin

Used to treat urinary tract infections

Sumatriptan

Imitrex

Used to treat migraines

Tetracyclines <>

tetracycline, doxycycline

Used to treat acne and urinary tract infections

Trazodone


Used for depression and sleep

Tricyclic antidepressants (avoid doxepin)

Elavil, Tofranil, Pamelor

Used to treat depression

Verapamil

Calan, Isoptin, Verelan

Used for high blood pressure



Potentially Hazardous
You should avoid or use these drugs with caution, particularly while breastfeeding a newborn or premature infant.

Name of Drug

Brand Name

Use

Acebutolol

Sectral

A beta blocker used to treat high blood pressure and abnormal heart rhythms.

Atenolol

Tenormin

A beta blocker used to treat high blood pressure and abnormal heart rhythms.

Antihistamine/decongestant combinations

Contac, Dimetapp

Used to treat colds and allergies; may reduce your milk supply

Benzodiazepines

long-acting Librium, Valium, Dalmane

Used to treat anxiety and for sleep (lorazepam, oxazepam preferred)

Chlorthalidone

Hygroton, Thalitone

Diuretic used to treat high blood pressure; may reduce milk supply

Citalopram

Celexa

Antidepressant; can cause infant drowsiness

Clindamycin

Cleocin

Used to treat abdominal and vaginal infections

Clonidine

Catapres

Used to treat high blood pressure, may reduce milk supply

Contraceptives (Estrogen-containing)

Ortho-Novum, Lo-Ovral, Loestrin

Used for birth control; may reduce milk supply

Doxepin

Sinequan

Used to treat depression

Egotamine

Cafergot

Used to treat migraines

Ethosuximide

Zarontin

Used to treat epilepsy

Fluorescein IV


Used to diagnose retinal problems

Fluoxetine

Prozac, Serafem

Used to treat depression

Iodinated contrast media


Used to examine kidneys; withhold breastfeeding temporarily

Lamotrigine

Lamictal

Used for seizures and mood disorders

Lithium (monitor infant serum levels)

Lithobid

Used to treat bipolar disease

Metronidazole

Flagyl

An antibiotic used to treat some intestinal and genital infections

Nadolol

Corgard

A beta blocker used to treat high blood pressure and heart problems

Narcotics, especially meperidine in addicts, or with high doses in neonates

Tylenol #3, Vicodin

Used for pain (one tablet every four hours maximum)

Nefazodone

Serzone

Used for depression

Nicotine



Nitrofurantoin

Macrobid

Used to treat urinary tract infections (safe after the baby is one month old

Phenobarbital, anticonvulsant doses


Sedative and anticonvulsant

Piroxicam

Feldene

Used to treat arthritis and pain

Primidone

Mysoline

Used to treat seizures

Reserpine


Used to treat hypertension

Sotalol

Betapace

Used to treat heart problems

Thiazide diuretics, long-acting or high doses

Aquatensin, Enduron, Lozol, Renese

For high blood pressure or edema

Venlafaxine

Effexor

Used to treat depression



Not safe to take
You shouldn't use any of these drugs while breastfeeding. If you must take them for health reasons, you should stop breastfeeding — either temporarily or permanently — depending on how long you need to take them. To keep your milk supply up you can "pump and dump" — that is, use a breast pump and discard what you collect until you're ready to breastfeed again.

Name of Drug

Brand Name

Use

Amantadine

Symmetrel

Used to treat the flu or Parkinson's disease; may reduce milk supply

Amiodarone

Cordarone

Used to treat heart problems

Antilipemics (excluding resins)

Lescol, Lipitor, Lopid, Mevacor, Pravacor, Zocor

Used to lower the level of cholesterol in the blood

Antineoplastic agents


Used to treat cancer

Aspirin (large doses)


Used to treat arthritis

Cocaine



Chlorampenicol


Used to treat serious infections

Clozapine

Clozaril

Used to treat schizophrenia

Dipyrone (dipirona in Mexican drugs)


Used for pain and inflammation

Gold Salts

Myochrysine

Used to treat arthritis

Iodide

Betadine

Used for douching

Lipid-lowering drugs

Baycol, Lescol, Lipitor, Lopid, Mevacor, Pravacor, Zocor

Used to lower the level of fats in the blood

Metamizole (Dipyrone)


Analgesic/anti-inflammatory. Banned in U.S. but available in Mexico

Salicyclates, large doses

Aspirin

Used to treat arthritis


source from http://www.babycenter.com

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